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Year : 2022  |  Volume : 28  |  Issue : 1  |  Page : 93-97

Recurrent submandibular pleomorphic adenoma with metastasis: Carcinoma ex pleomorphic adenoma

1 Department of General Surgery, Medical College Hospital, Kozhikode, Kerala, India
2 Department of General Surgery, Government Medical College, Kozhikode, Kerala, India

Correspondence Address:
Dr. Ajil Antony
Department of General Surgery, Medical College Hospital, Kozhikode - 673 001, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ksj.ksj_52_21

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Carcinoma ex pleomorphic adenoma (CXPA) is a carcinoma arising from a primary or recurrent benign PA. The entity is difficult to diagnose preoperatively. PA is a common neoplasm that arises from the major salivary glands and infrequently undergoes a malignant transformation. PA can metastasise without histological malignant transformation. Malignant changes in PA are associated with a long duration, tumour recurrence, radiation therapy, advancing age and tumour size. Since the incidence of malignancy is correlated with the duration of PA, the risk of developing malignancy is only about 1.5% for a duration of <5 years, but increases to 9.5% for a duration of >15 years. We describe a case of CXPA of submandibular salivary gland in a 70-year-old female who had a history of right submandibular sialoadenectomy in 2017 and then redo excisions at the same site in 2018 and 2021.

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