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ORIGINAL ARTICLE
Year : 2021  |  Volume : 27  |  Issue : 2  |  Page : 169-172

Neoadjuvant chemotherapy in cancer breast


1 Department of General Surgery, Government Medical College, Alappuzha, Kerala, India
2 Department of General Surgery, Government Medical College, Trivandrum, Kerala, India

Correspondence Address:
Dr. Jiya Mulayamkuzhiyi Saju
Vattamala (H), Manarcadu P. O., Kottayam - 686 019, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ksj.ksj_33_21

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Introduction: This observational study attempts to assess the proportion of carcinoma breast patients showing complete pathological response to neoadjuvant chemotherapy post-surgery and to study the factors contributing to complete pathological response. Subjects and Methods: This was conducted on 290 female patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy (NACT) followed by surgery in the Department of General Surgery from April 2018 to April 2020. The post-operative histopathological specimen was checked for evidence of pathological complete response (pCR). Statistical analysis was done using SPSS software. Results: The proportion of breast cancer patients with pCR following NACT was 18.6% (54 out of 290 patients). Factors found to have a significant association with pCR were the clinical size of tumour, size of lump in mammogram, histological grade of tumour and duration of swelling. Clinical stage, molecular subtype of cancer and age had no significant association with pCR. Conclusion: Less advanced tumours i.e., those with clinical and mammogram size ≤5 cm achieved higher pCR than more advanced tumours. Higher histological grade achieved less pCR than histological Grade I tumours. Association could not be elicited between pCR and triple-negative molecular subtype.


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