| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 27
| Issue : 2 | Page : 111-115 |
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Alterations in liver function test following laparoscopic cholecystectomy
M Anjin Anand, Joji I Maliekal
Department of General Surgery, MES Medical College, Kolathur, Kerala, India
Correspondence Address:
M Anjin Anand
Department of General Surgery, MES Medical College, Perinthalmanna, Kolathur - 679 322, Kerala
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/ksj.ksj_39_21
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Introduction: CO2 pneumoperitoneum induced increased intra-abdominal pressure during laparoscopic procedures produces transient reduction in hepatic blood flow liver enzyme elevation. Aims and Objectives: The aim of this study is to study the alteration of liver function test (LFT) parameters such as aspartate aminotransferase/serum glutamic-oxaloacetic transaminase (SGOT), alanine-aminotransferase/serum glutamic-pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and serum bilirubin (total and direct) in patients undergoing laparoscopic cholecystectomy. Materials and Methods: A prospective, cross-sectional study was conducted. The sample size was 50. Data collected were analysed using the SSPS software version 17. Results: Three quarters were females. The mean age of the study population was 48.5 ± 13.1 years, males having higher mean age of 57.0 ± 8.5 years compared to 45.5 ± 13.2 years for females. The SGOT, SGPT, ALP and bilirubin levels were significantly increased on the next day of surgery. There was a significant positive correlation between SGOT and SGPT levels on day 1 to the increased duration of pneumoperitoneum with correlation coefficient of 0.859 and 0.449, respectively. SGOT and SGPT levels were increased significantly in 61–80 years age group. Conclusion: The duration of pneumoperitoneum had a great effect on the LFT changes after surgery. Age influenced changes in SGOT and SGPT levels.
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